Medical Wikipedia : The Medical Encyclopedia
Difference between revisions of "Microfold Cells"
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== Microfold Cells or M Cells == | == Microfold Cells or M Cells == | ||
== Where the M Cells present? == | |||
Microfold Cells or M Cells are present in follicle-associated epithelium (FAE) | Microfold Cells or M Cells are present in follicle-associated epithelium (FAE) | ||
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M cells are seen in epithelial cells of the mucosa-associated lymphoid tissues. | M cells are seen in epithelial cells of the mucosa-associated lymphoid tissues. | ||
== What is function of the M Cells? == | |||
M cells helps to transport antigens from intestinal lumen to immune system cells, and starts | M cells helps to transport antigens from intestinal lumen to immune system cells, and starts | ||
an immune response or tolerance | an immune response or tolerance. | ||
M cells function are phagocytosis and transcytosis. M cells are capable of taking up large particulate antigens from the lumen and transporting them intact into the subepithelial space. | |||
== What is function of the M Cells in polio virus infection? == | |||
M cells express lectin-like molecules in the apical surface. These molecules help to promote binding to specific pathogens such as poliovirus. | M cells express lectin-like molecules in the apical surface. These molecules help to promote binding to specific pathogens such as poliovirus. | ||
M cells | == What is the mechanism where M cells involved with IgA response in payer patches? == | ||
Antigens that bind to the M cell and are transported to the underlying Peyer patches generally elicit a positive (IgA) response. | Antigens that bind to the M cell and are transported to the underlying Peyer patches generally elicit a positive (IgA) response. | ||
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Once antigens enter the Peyer patch, TGF-β-secreting T cells promote B cell isotype switching to IgA. | Once antigens enter the Peyer patch, TGF-β-secreting T cells promote B cell isotype switching to IgA. | ||
----If Peyer patch B cells are absent then M cells are also absent. [M cells have not seen in B cell–deficient animals, which lack Peyer patches] | |||
If Peyer patch B cells are absent then M cells are also absent. [M cells have not seen in B cell–deficient animals, which lack Peyer patches] | |||
Peyer patches have T cell-dependent areas and B cell-dependent/germinal centers typical of lymph nodes, but only efferent lymphatics. | Peyer patches have T cell-dependent areas and B cell-dependent/germinal centers typical of lymph nodes, but only efferent lymphatics. | ||
[[Category:Medicine]] | |||
[[Category:Internal Medicine]] | |||
[[Category:Molecular Biology]] | |||
[[Category:Gastroenterology]] | |||
[[Category:Immune System]] | |||
[[Category:Immunoglobulins]] | |||
Revision as of 10:58, 2 March 2022
Microfold Cells or M Cells
Where the M Cells present?
Microfold Cells or M Cells are present in follicle-associated epithelium (FAE)
Follicle -associated epithelium is a specialized epithelium present over Peyer’s patch in small intestine and isolated lymphoid follicles.
M cells are seen in epithelial cells of the mucosa-associated lymphoid tissues.
What is function of the M Cells?
M cells helps to transport antigens from intestinal lumen to immune system cells, and starts
an immune response or tolerance.
M cells function are phagocytosis and transcytosis. M cells are capable of taking up large particulate antigens from the lumen and transporting them intact into the subepithelial space.
What is function of the M Cells in polio virus infection?
M cells express lectin-like molecules in the apical surface. These molecules help to promote binding to specific pathogens such as poliovirus.
What is the mechanism where M cells involved with IgA response in payer patches?
Antigens that bind to the M cell and are transported to the underlying Peyer patches generally elicit a positive (IgA) response.
M cell helps to connect Peyer patches and lymphoid follicles as conduit.
Once antigens enter the Peyer patch, TGF-β-secreting T cells promote B cell isotype switching to IgA.
If Peyer patch B cells are absent then M cells are also absent. [M cells have not seen in B cell–deficient animals, which lack Peyer patches]
Peyer patches have T cell-dependent areas and B cell-dependent/germinal centers typical of lymph nodes, but only efferent lymphatics.